Spisak kliničkih ispitivanja

Bezbednost i efikasnost proizvoda iz linije Gengigel potvrđene su u brojnim kliničkim ispitivanjima:

  1. de Araújo Nobre M, Cintra N, Maló P. Peri-implant maintenance of immediate function implants: a pilot study comparing hyaluronic acid and chlorhexidine. Int J Dent Hyg. 2007;5(2):87-94.
  2. Boychuk-Tovsta OG, Rozhko MM. Clinical evaluation of 0,2% hyaluronic acid containing gel “Gengigel” in the local treatment of pregnant women with generalized periodontitis on the background of IDA. The Pharma Innovation Journal 2017; 6(5): 79-81.
  3. Chauhan, AS; Bains, VK; Gupta, V; Singh, GP; Patil, SS. Comparative analysis of hyaluronan gel and xanthan-based chlorhexidine gel, as adjunct to scaling and root planing with scaling and root planing alone in the treatment of chronic periodontitis: A preliminary study. Contemp Clin Dent. 2013; 4(1): 54-61.
  4. Dubovina D, Mihailović B, Bukumirić Z, Vlahović Z, Miladinović M, Miković N, Lazić Z. The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis. Vojnosanit Pregl 2016; 73(11): 1010–1015.
  5. Eick S, Renatus A, Heinicke M, Pfister W, Stratul SI, Jentsch H. Hyaluronic Acid as an adjunct after scaling and root planing: a prospective randomized clinical trial. J Periodontol. 2013 Jul;84(7):941-9.
  6. Fawzy El-Sayed, KM; Dahaba, MA; Aboul-Ela, S; Darhous, MS. Local application of hyaluronan gel in conjunction with periodontal surgery: a randomized controlled trial. Clin Oral Investig. 2012; 16(4): 1229-36.
  7. Gocmen G, Gonul O, Oktay NS, Yarat A, Goker K. The antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction. J Craniomaxillofac Surg. 2015 Sep;43(7):1033-7.
  8. Gontiya, G; Galgali, SR. Effect of hyaluronan on periodontitis: A clinical and histological study. J Indian Soc Periodontol. 2012; 16(2): 184-92.
  9. Gupta, S; Kediege, SD; Gupta, A; Jain, K. Evaluation of GENGIGEL® Application in the Management of Furcation with Coronally Advanced Flap through Surgical Re-Entry-A Split Mouth Clinical Study. J Clin Diagn Res. 2017; 11(1): ZC27-ZC32.
  10. Jain Y. Clinical evaluation of 0.2% hyaluronic acid containing gel in the treatment of gingivitis. Med J DY Patil Univ 2013; 6:416-20.
  11. Jentsch H, Pomowski R, Kundt G, Göcke R. Treatment of gingivitis with hyaluronan. J Clin Periodontol. 2003 Feb;30(2):159-64.
  12. Johannsen A, Tellefsen M, Wikesjö U, Johannsen G. Local delivery of hyaluronan as an adjunct to scaling and root planing in the treatment of chronic periodontitis. J Periodontol. 2009 Sep;80(9):1493-7.
  13. Koray, M; Ofluoglu, D; Onal, EA; Ozgul, M; Ersev, H; Yaltirik, M; Tanyeri, H. Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars. Int J Oral Maxillofac Surg. 2014; 43(11): 1399-403.
  14. Koshal A, Bolt R, Galgut P. A comparison in postoperative healing of sites receiving non-surgical debridement augmented with and without a single application of hyaluronan 0.8% gel. Dental Tribune. 2007.
  15. Kumar R, Srinivas M, Pai J, Suragimath G, Prasad K, Polepalle T. Efficacy of hyaluronic acid (hyaluronan) in root coverage procedures as an adjunct to coronally advanced flap in Millers Class I recession: A clinical study. J Indian Soc Periodontol. 2014 Nov-Dec;18(6):746-50.
  16. Lee JH, Jung JY, Bang D. The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet's disease. J Eur Acad Dermatol Venereol. 2008 May;22(5):590-5.
  17. Lobato JCRF, Dos Santos Vilhena MA, Izidoro C, Alves RC, Proença L. Single application of 0.8% hyaluronic acid as a coadjuvant of nonsurgical treatment in nonsmoking patients with periodontitis: A split-mouth, randomized, controlled pilot clinical trial. J Indian Soc Periodontol. 2019 Nov-Dec;23(6):545-548.
  18. Mantovani S, Sala Tesciat A, Fossati B. Preliminary clinical evaluation of a hyaluronic acid-based product in oral disorders: double-blind trial. Attualità Terapeutica Internazionale. 1998; anno XVI.
  19. Mesa, FL; Aneiros, J; Cabrera, A; Bravo, M; Caballero, T; Revelles, F; del Moral, RG; O'Valle, F. Antiproliferative effect of topic hyaluronic acid gel. Study in gingival biopsies of patients with periodontal disease. Histol Histopathol. O; 17(3): 747-53.
  20. Pagnacco A., Vangelisti R., Erra C., Poma A. Studio clinico in doppio cieco verso placebo di un nuovo gel gengivale a base di sodio ialuronato. Attualità Terapeutica Internazionale, 1997, anno XV 4: 1-7.
  21. Pistorius, A; Martin, M; Willershausen, B; Rockmann, P. The clinical application of hyaluronic acid in gingivitis therapy. Quintessence Int. 2005; 36(7-8): 531-8.
  22. Polepalle, T; Srinivas, M; Swamy, N; Aluru, S; Chakrapani, S; Chowdary, BA. Local delivery of hyaluronan 0.8% as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A clinical and microbiological study. J Indian Soc Periodontol. 2015; 19(1): 37-42.
  23. Pomowski R., Kundt G., Gocke R., Jentsch H. Treatment of Gingivitis with Hyaluronan. Journal of Clinical Periodontology 2003, 30: 159-164.
  24. Rajan, P; Baramappa, R; Rao, NM; Pavaluri, AK; P, I; Rahaman, SM. Hyaluronic Acid as an adjunct to scaling and root planing in chronic periodontitis. A randomized clinical trial. J Clin Diagn Res. 2014; 8(12): ZC11-4.
  25. Rodrigues, SV; Acharya, AB; Bhadbhade, S; Thakur, SL. Hyaluronan-containing mouthwash as an adjunctive plaque-control agent. Oral Health Prev Dent. 2010; 8(4): 389-94.
  26. Rosu S, Montanaro F, Rosu A, Oancea R. A randomized, open-label, parallel-group multicentre study on the efficacy and tolerability of a nonmedicated, patented gel for the relief of teething symptoms in infants. Italian Journal of Dental Medicine 2017; July.
  27. Sahayata, VN; Bhavsar, NV; Brahmbhatt, NA. An evaluation of 0.2% hyaluronic acid gel (GENGIGEL®) in the treatment of gingivitis: a clinical & microbiological study. Oral Health Dent Manag. 2014; 13(3): 779-85.
  28. Sapna N, Vandana KL. Evaluation of hyaluronan gel (GENGIGEL®) as a topical applicant in the treatment of gingivitis. J Investig Clin Dent. 2011 Aug;2(3):162-70.
  29. Shah SA, Vijayakar HN, Rodrigues SV, Mehta CJ, Mitra DK, Shah RA. To compare the effect of the local delivery of hyaluronan as an adjunct to scaling and root planing versus scaling and root planing alone in the treatment of chronic periodontitis. J Indian Soc Periodontol 2016; 20:549-56.
  30. Sharma, V; Gupta, R; Dahiya, P; Kumar, M. Comparative evaluation of coenzyme Q10-based gel and 0.8% hyaluronic acid gel in treatment of chronic periodontitis. J Indian Soc Periodontol. 2016; 20(4): 374-380.
  31. Vangelisti R., Pagnacco O., Erra C. Hyaluronic acid in the topical treatment of gingival inflammations: preliminary clinical trial. Attualità Terapeutica Internazionale. 1997; anno XV.
  32. Xu, Y; Höfling, K; Fimmers, R; Frentzen, M; Jervøe-Storm, PM. Clinical and microbiological effects of topical subgingival application of hyaluronic acid gel adjunctive to scaling and root planing in the treatment of chronic periodontitis. J Periodontol. 2004; 75(8): 1114-8.
  33. Yıldırım S, Özener HÖ, Doğan B, Kuru B. Effect of Topically-Applied Hyaluronic-Acid on Pain and Palatal Epithelial Wound Healing: An Examiner-Blind, Randomized, Controlled Clinical Trial. J Periodontol. 2017 Sep 15:1-14.
  34. Yilmaz N, Demirtas N, Kazancioglu HO, Bayer S, Acar AH, Mihmanli A. The efficacy of hyaluronic acid in post-extraction sockets of impacted third molars: A pilot study. Niger J Clin Pract. 2017 Dec; 20(12): 1626-1631.